Identification of Novel Melanin Synthesis Inhibitors From Crataegus pycnoloba Using an in Vivo Zebrafish Phenotypic Assay

• Main Authors: Adamantia Agalou (Author), Michael Thrapsianiotis (Author), Apostolis Angelis (Author), Athanasios Papakyriakou (Author), Alexios-Leandros Skaltsounis (Author), Nektarios Aligiannis (Author), Dimitris Beis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zebrafish has emerged as a powerful model organism for high throughput drug screening. Several morphological criteria, transgenic lines and in situ expression screens have been developed to identify novel bioactive compounds and their mechanism of action. Here, we used the inhibition of melanogenesi...