Using Colistin as a Trojan Horse: Inactivation of Gram-Negative Bacteria with Chlorophyllin

• Main Authors: Peter Richter (Author), Marcus Krüger (Author), Binod Prasad (Author), Susanne Gastiger (Author), Mona Bodenschatz (Author), Florian Wieder (Author), Andreas Burkovski (Author), Walter Geißdörfer (Author), Michael Lebert (Author), Sebastian M. Strauch (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colistin (polymyxin E) is a membrane-destabilizing antibiotic used against Gram-negative bacteria. We have recently reported that the outer membrane prevents the uptake of antibacterial chlorophyllin into Gram-negative cells. In this study, we used sub-toxic concentrations of colistin to weaken this...