Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

• Main Authors: Peifeng Tang (Author), Zhijun Tan (Author), Vivekh Ehamparanathan (Author), Tingwei Ren (Author), Laurel Hoffman (Author), Cheng Du (Author), Yuanli Song (Author), Li Tao (Author), Angela Lewandowski (Author), Sanchayita Ghose (Author), Zheng Jian Li (Author), Shijie Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Disulfide bonds play a crucial role in folding and structural stabilization of monoclonal antibodies (mAbs). Disulfide bond reduction may happen during the mAb manufacturing process, resulting in low molecular weight species and possible failure to meet product specifications. Although many mitigati...