Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting

Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting

Engineered nuclease-mediated gene targeting through homologous recombination (HR) in hematopoietic stem and progenitor cells (HSPCs) has the potential to treat a variety of genetic hematologic and immunologic disorders. Here, we identify critical parameters to reproducibly achieve high frequencies o...

Full description

Saved in:
Bibliographic Details
Main Authors: Carsten T. Charlesworth (Author), Joab Camarena (Author), M. Kyle Cromer (Author), Sriram Vaidyanathan (Author), Rasmus O. Bak (Author), Jason M. Carte (Author), Jason Potter (Author), Daniel P. Dever (Author), Matthew H. Porteus (Author)
Format: Book
Published: Elsevier, 2018-09-01T00:00:00Z.
Subjects:
article
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available

Similar Items