Involvement of Endothelin and ETAEndothelin Receptor in Mechanical Allodynia in Mice Given Orthotopic Melanoma Inoculation

• المؤلفون الرئيسيون: Masahide Fujita (مؤلف), Tsugunobu Andoh (مؤلف), Ikuo Saiki (مؤلف), Yasushi Kuraishi (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2008-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

We investigated whether endothelin (ET) would be involved in skin cancer pain in mice. Orthotopic inoculation of B16-BL6 melanoma cells into the plantar region of the hind paw produced marked mechanical allodynia in C57BL/6 mice. Intraplantar injections of the ETA- receptor antagonist BQ-123 (0.3 -3...