Postponement of the opacification of lentoid bodies derived from human induced pluripotent stem cells after lanosterol treatment-the first use of the lens aging model in vitro in cataract drug screening

• Автори: Lifang Zhang (Автор), Zhenwei Qin (Автор), Danni Lyu (Автор), Bing Lu (Автор), Zhijian Chen (Автор), Qiuli Fu (Автор), Ke Yao (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Purpose: Our previous study observed that human induced pluripotent stem cell (HiPSC)-derived lentoid bodies (LBs) became cloudy with extended culture time, partially mimicking the progress of human age-related cataracts (ARCs) in a dish. In the present study, lanosterol, a potential anticataract dr...