Postponement of the opacification of lentoid bodies derived from human induced pluripotent stem cells after lanosterol treatment-the first use of the lens aging model in vitro in cataract drug screening

• Main Authors: Lifang Zhang (Author), Zhenwei Qin (Author), Danni Lyu (Author), Bing Lu (Author), Zhijian Chen (Author), Qiuli Fu (Author), Ke Yao (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Purpose: Our previous study observed that human induced pluripotent stem cell (HiPSC)-derived lentoid bodies (LBs) became cloudy with extended culture time, partially mimicking the progress of human age-related cataracts (ARCs) in a dish. In the present study, lanosterol, a potential anticataract dr...