Postponement of the opacification of lentoid bodies derived from human induced pluripotent stem cells after lanosterol treatment-the first use of the lens aging model in vitro in cataract drug screening

• Những tác giả chính: Lifang Zhang (Tác giả), Zhenwei Qin (Tác giả), Danni Lyu (Tác giả), Bing Lu (Tác giả), Zhijian Chen (Tác giả), Qiuli Fu (Tác giả), Ke Yao (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Purpose: Our previous study observed that human induced pluripotent stem cell (HiPSC)-derived lentoid bodies (LBs) became cloudy with extended culture time, partially mimicking the progress of human age-related cataracts (ARCs) in a dish. In the present study, lanosterol, a potential anticataract dr...