Modeling Favipiravir Antiviral Efficacy Against Emerging Viruses: From Animal Studies to Clinical Trials

• Main Authors: Vincent Madelain (Author), France Mentré (Author), Sylvain Baize (Author), Xavier Anglaret (Author), Cédric Laouénan (Author), Lisa Oestereich (Author), Thi Huyen Tram Nguyen (Author), Denis Malvy (Author), Géraldine Piorkowski (Author), Frederik Graw (Author), Stephan Günther (Author), Hervé Raoul (Author), Xavier deLamballerie (Author), Jérémie Guedj (Author)
• Format: Book
• Published: Wiley, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In 2014, our research network was involved in the evaluation of favipiravir, an anti‐influenza polymerase inhibitor, against Ebola virus. In this review, we discuss how mathematical modeling was used, first to propose a relevant dosing regimen in humans, and then to optimize its antiviral efficacy i...