Discovery of novel thiosemicarbazone derivatives with potent and selective anti-Candida glabrata activity

• मुख्य लेखकों: Xianru Li (लेखक), Liping Li (लेखक), Haonan Zhang (लेखक), Xiaochen Chi (लेखक), Yuanying Jiang (लेखक), Tingjunhong Ni (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A series of 21 novel compounds containing a thiosemicarbazone moiety were designed and synthesised based on hit compound 1 from our in-house compound library screening. Most compounds showed potent antifungal activity in vitro against seven common pathogenic fungi. Notably, all compounds showed high...