Discovery of novel thiosemicarbazone derivatives with potent and selective anti-Candida glabrata activity

• Main Authors: Xianru Li (Author), Liping Li (Author), Haonan Zhang (Author), Xiaochen Chi (Author), Yuanying Jiang (Author), Tingjunhong Ni (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

A series of 21 novel compounds containing a thiosemicarbazone moiety were designed and synthesised based on hit compound 1 from our in-house compound library screening. Most compounds showed potent antifungal activity in vitro against seven common pathogenic fungi. Notably, all compounds showed high...