Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: The Role of GSK-3β in the Maintenance of Steady-State Levels of Insulin Receptor Signaling Molecules and Nav1.7 Sodium Channel in Adrenal Chromaffin Cells

• Main Authors: Takayuki Nemoto (Author), Toshihiko Yanagita (Author), Tasuku Kanai (Author), Akihiko Wada (Author)
• Formato: Livro
• Publicado em: Elsevier, 2009-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Glycogen synthase kinase-3 (GSK-3) is constitutively active in nonstimulated cells, where the majority of its substrates undergo inactivation/proteolysis by phosphorylation. Extracellular stimuli (e.g., insulin) catalyze inhibitory Ser9-phosphorylation of GSK-3β, turning on signaling and causing oth...