Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids

• প্রধান লেখক: Marc Nothisen (লেখক), Phanélie Perche-Létuvée (লেখক), Jean-Paul Behr (লেখক), Jean-Serge Remy (লেখক), Mitsuharu Kotera (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2018-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

We report the evaluation of 18-mer 2'-O-methyl-modified ribose oligonucleotides with a full-length phosphorothioate backbone chemically conjugated at the 5' end to the oligospermine units (Sn-: n = 5, 15, 20, 25, and 30 [number of spermine units]) as splice switching oligonucleotides (SSOs...