Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids
We report the evaluation of 18-mer 2'-O-methyl-modified ribose oligonucleotides with a full-length phosphorothioate backbone chemically conjugated at the 5' end to the oligospermine units (Sn-: n = 5, 15, 20, 25, and 30 [number of spermine units]) as splice switching oligonucleotides (SSOs...
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| Main Authors: | , , , , |
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| Format: | Book |
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Elsevier,
2018-12-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |