Use of poxvirus display to select antibodies specific for complex membrane antigens

• Main Authors: Ernest S. Smith (Author), Leslie A. Balch (Author), Maria Scrivens (Author), Shuying Shi (Author), Wei Wang (Author), Caroline D. Harvey (Author), Angelica A. Cornelison (Author), Malgorzata Gil-Moore (Author), Renee A. Kirk (Author), Loretta L. Mueller (Author), Richard L. Hall (Author), Alan P. Howell (Author), Christine A. Reilly (Author), Jessica M. Mayer (Author), Francis G. Murante (Author), Kari A Viggiani (Author), Elaine M. Gersz (Author), Holm Bussler (Author), Madeleine R. Keefe (Author), Elizabeth E. Evans (Author), Mark J. Paris (Author), Maurice Zauderer (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTAntibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs and into the membrane of poxvirus. The protein of...