Generation of Hydrogen Peroxide and Downstream Protein Kinase D1 Signaling Is a Common Feature of Inducers of Pancreatic Acinar-to-Ductal Metaplasia

• Main Authors: Heike R. Döppler (Author), Geou-Yarh Liou (Author), Peter Storz (Author)
• Formato: Libro
• Publicado: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Pancreatic acinar-to-ductal metaplasia (ADM) is a reversible process that occurs after pancreatic injury, but becomes permanent and leads to pancreatic lesions in the presence of an oncogenic mutation in KRAS,. While inflammatory macrophage-secreted chemokines, growth factors that activate epidermal...