Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1<i>H</i>-1,2,4-triazoles and 1-(Diarylmethyl)-1<i>H</i>-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

• Main Authors: Gloria Ana (Author), Patrick M. Kelly (Author), Azizah M. Malebari (Author), Sara Noorani (Author), Seema M. Nathwani (Author), Brendan Twamley (Author), Darren Fayne (Author), Niamh M. O'Boyle (Author), Daniela M. Zisterer (Author), Elisangela Flavia Pimentel (Author), Denise Coutinho Endringer (Author), Mary J. Meegan (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)-positive MCF-7 breast cancer cells identified 5-((2<i>H<...