Melatonin Rescued Reactive Oxygen Species-Impaired Osteogenesis of Human Bone Marrow Mesenchymal Stem Cells in the Presence of Tumor Necrosis Factor-Alpha

• Main Authors: Xianjian Qiu (Author), Xudong Wang (Author), Jincheng Qiu (Author), Yuanxin Zhu (Author), Tongzhou Liang (Author), Bo Gao (Author), Zizhao Wu (Author), Chengjie Lian (Author), Yan Peng (Author), Anjing Liang (Author), Peiqiang Su (Author), Dongsheng Huang (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulation of reactive oxygen species (ROS), which can be induced by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), can significantly inhibit the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). This process can contribute to the imbalance of bone rem...