Image-Based Quantification of Gold Nanoparticle Uptake and Localization in 3D Tumor Models to Inform Radiosensitization Schedule

• Main Authors: Ljubica Z. Petrovic (Author), Michael Oumano (Author), Justin Hanlon (Author), Mark Arnoldussen (Author), Igor Koruga (Author), Sayeda Yasmin-Karim (Author), Wilfred Ngwa (Author), Jonathan Celli (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gold nanoparticles (GNPs) have shown particular promise as radiosensitizing agents and as complementary drug delivery agents to improve therapeutic index in cancer treatment. Optimal implementation, however, depends critically on the localization of GNPs at the time of irradiation, which, in turn, d...