Ivabradine Reduces Chemokine-Induced CD4-Positive Lymphocyte Migration

• Main Authors: Thomas Walcher (Author), Peter Bernhardt (Author), Dusica Vasic (Author), Helga Bach (Author), Renate Durst (Author), Wolfgang Rottbauer (Author), Daniel Walcher (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims. Migration of CD4-positive lymphocytes into the vessel wall is a critical step in atherogenesis. Recent data suggest that ivabradine, a selective I(f)-channel blocker, reduces atherosclerotic plaque formation in apolipoprotein E-deficient mice, hitherto nothing is known about the mechanism by w...