Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity

• Main Authors: Yuhei eNishimura (Author), Shota eSasagawa (Author), Michiko eAriyoshi (Author), Sayuri eIchikawa (Author), Yasuhito eShimada (Author), Koki eKawaguchi (Author), Reiko eKawase (Author), Reiko eYamamoto (Author), Takuma eUehara (Author), Takaaki eYanai (Author), Ryoji eTakata (Author), Toshio eTanaka (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Both caloric restriction and resveratrol have beneficial effects on obesity. However, the biochemical pathways that mediate these beneficial effects might be complex and interconnected and have not been fully elucidated. To reveal the common therapeutic mechanism of caloric restriction and resveratr...