Study of the ketohexokinase inhibitor PF‐06835919 as a clinical cytochrome P450 3A inducer: Integrated use of oral midazolam and liquid biopsy

• Main Authors: Ruolun Qiu (Author), Kari Fonseca (Author), Arthur Bergman (Author), Jian Lin (Author), David Tess (Author), Lauren Newman (Author), Alia Fahmy (Author), Zivile Useckaite (Author), Andrew Rowland (Author), Manoli Vourvahis (Author), David Rodrigues (Author)
• Format: Book
• Published: Wiley, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract PF‐06835919, a ketohexokinase inhibitor, presented as an inducer of cytochrome P450 3A4 (CYP3A4) in vitro (human primary hepatocytes), and static mechanistic modeling exercises predicted significant induction in vivo (oral midazolam area under the plasma concentration‐time curve [AUC] ratio...