4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

• Main Authors: Jong Y. Lee (Author), Geum J. Kim (Author), Jin K. Choi (Author), Young-Ae Choi (Author), Na-Hee Jeong (Author), Pil-Hoon Park (Author), Hyukjae Choi (Author), Sang-Hyun Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is a progressive autoimmune disease specific to synovial joints; it causes joint damage and other systemic abnormalities, thereby leading to physical disability and early mortality. Marine sponge-derived fungi, Pestalotiopsis sp., secrete immunosuppressive compounds in the...