Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

• Main Authors: Mazin A. A. Najm (Author), Walaa R. Mahmoud (Author), Azza T. Taher (Author), Safinaz E-S. Abbas (Author), Fadi M. Awadallah (Author), Heba Abdelrasheed Allam (Author), Daniela Vullo (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111. Six series of a substituted benzoylthioureido core were prepared featuring different zinc...