Tofacitinib Represses the Janus Kinase-Signal Transducer and Activators of Transcription Signalling Pathway in Keratinocytes

• প্রধান লেখক: Ankit Srivastava (লেখক), Mona Ståhle (লেখক), Andor Pivarcsi (লেখক), Enikö Sonkoly (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Medical Journals Sweden, 2018-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Tofacitinib is a Janus kinase (JAK) inhibitor, which has shown efficacy in treating psoriasis. The mode of action of tofacitinib is not completely understood but it has been thought to be mediated by the inhibition of CD4+ T-cell activation. Here, we investigated whether the molecular targets of tof...