Tofacitinib Represses the Janus Kinase-Signal Transducer and Activators of Transcription Signalling Pathway in Keratinocytes

• मुख्य लेखकों: Ankit Srivastava (लेखक), Mona Ståhle (लेखक), Andor Pivarcsi (लेखक), Enikö Sonkoly (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Medical Journals Sweden, 2018-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Tofacitinib is a Janus kinase (JAK) inhibitor, which has shown efficacy in treating psoriasis. The mode of action of tofacitinib is not completely understood but it has been thought to be mediated by the inhibition of CD4+ T-cell activation. Here, we investigated whether the molecular targets of tof...