DAGLα Inhibition as a Non-invasive and Translational Model of Episodic Headache

• Main Authors: Aidan Levine (Author), Erika Liktor-Busa (Author), Kelly L. Karlage (Author), Luigi Giancotti (Author), Daniela Salvemini (Author), Todd W. Vanderah (Author), Tally M. Largent-Milnes (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent findings suggested that Clinical Endocannabinoid Deficiency underlies the pathophysiology of pain disorders, including migraine and headache. In models of medication overuse headache induced by sustained administration of sumatriptan or morphine, 2-AG levels were selectively depleted in the p...