The Active Glucuronide Metabolite of the Brain Protectant IMM-H004 with Poor Blood-Brain Barrier Permeability Demonstrates a High Partition in the Rat Brain via Multiple Mechanisms

• Главные авторы: Jianwei Jiang (Автор), Lijun Luo (Автор), Ziqian Zhang (Автор), Xiao Liu (Автор), Naihong Chen (Автор), Yan Li (Автор), Li Sheng (Автор)
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• Опубликовано: MDPI AG, 2024-02-01T00:00:00Z.
• Предметы: article
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Background: Glucuronidation is an essential metabolic pathway for a variety of drugs. IMM-H004 is a novel neuroprotective agent against ischemic stroke, and its glucuronide metabolite IMM-H004G exhibits similar pharmacological activity. Despite possessing a higher molecular weight and polarity, brai...