Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis

• Main Authors: Sarah A. Hansen (Author), Marcia L. Hart (Author), Susheel Busi (Author), Taybor Parker (Author), Angela Goerndt (Author), Kevin Jones (Author), James M. Amos-Landgraf (Author), Elizabeth C. Bryda (Author)
• Format: Bog
• Udgivet: The Company of Biologists, 2016-10-01T00:00:00Z.
• Fag: article
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Somatic mutations in the Tp53 tumor suppressor gene are the most commonly seen genetic alterations in cancer, and germline mutations in Tp53 predispose individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulat...