Assessment of the regenerative potential of macro-porous chitosan-calcium simvastatin scaffolds on bone cells

• Main Authors: Marjorie de Oliveira GALLINARI (Author), Ester Alves Ferreira BORDINI (Author), Vitor de Toledo STUANI (Author), Fernanda Balestrero CASSIANO (Author), Camila Correa da Silva Braga de MELO (Author), Juliano Milanezi de ALMEIDA (Author), Luciano Tavares Ângelo CINTRA (Author), Carlos Alberto DE SOUZA COSTA (Author), Diana Gabriela SOARES (Author)
• Format: Book
• Published: Sociedade Brasileira de Pesquisa Odontológica, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study evaluated the bioactive potential of a macro-porous chitosan scaffold incorporated with calcium hydroxide (CH-Ca) and functionalized with bioactive doses of simvastatin (SV) for bone tissue regeneration. Initially, the bioactive dose of SV in osteoblastic cells (SAOS-2) was deter...