Quantitative Nuclear Histomorphometry Predicts Molecular Subtype and Clinical Outcome in Medulloblastomas: Preliminary Findings

• Main Authors: Jon Whitney (Author), Liisa Dollinger (Author), Benita Tamrazi (Author), Debra Hawes (Author), Marta Couce (Author), Julia Marcheque (Author), Alexander Judkins (Author), Ashley Margol (Author), Anant Madabhushi (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Molecular subtypes of medulloblastoma [Sonic Hedgehog (SHH), Wingless/INT (WNT), Group 3, and Group 4] are defined by common patterns of gene expression. These differential gene expression patterns appear to result in different histomorphology and prognosis. Quantitative histomorphometry is a well-k...