A reliable transcriptomic risk-score applicable to formalin-fixed paraffin-embedded biopsies improves outcome prediction in localized prostate cancer

• Main Authors: Michael Rade (Author), Markus Kreuz (Author), Angelika Borkowetz (Author), Ulrich Sommer (Author), Conny Blumert (Author), Susanne Füssel (Author), Catharina Bertram (Author), Dennis Löffler (Author), Dominik J. Otto (Author), Livia A. Wöller (Author), Carolin Schimmelpfennig (Author), Ulrike Köhl (Author), Ann-Cathrin Gottschling (Author), Pia Hönscheid (Author), Gustavo B. Baretton (Author), Manfred Wirth (Author), Christian Thomas (Author), Friedemann Horn (Author), Kristin Reiche (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Clinical manifestation of prostate cancer (PCa) is highly variable. Aggressive tumors require radical treatment while clinically non-significant ones may be suitable for active surveillance. We previously developed the prognostic ProstaTrend RNA signature based on transcriptome‐w...