Dual Functionalized Liposomes for Selective Delivery of Poorly Soluble Drugs to Inflamed Brain Regions

• Main Authors: Sabrina Giofrè (Author), Antonio Renda (Author), Silvia Sesana (Author), Beatrice Formicola (Author), Barbara Vergani (Author), Biagio Eugenio Leone (Author), Vanna Denti (Author), Giuseppe Paglia (Author), Serena Groppuso (Author), Valentina Romeo (Author), Luca Muzio (Author), Andrea Balboni (Author), Andrea Menegon (Author), Antonia Antoniou (Author), Arianna Amenta (Author), Daniele Passarella (Author), Pierfausto Seneci (Author), Sara Pellegrino (Author), Francesca Re (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dual functionalized liposomes were developed to cross the blood-brain barrier (BBB) and to release their cargo in a pathological matrix metalloproteinase (MMP)-rich microenvironment. Liposomes were surface-functionalized with a modified peptide deriving from the receptor-binding domain of apolipopro...