Complex Inheritance of Rare Missense Variants in PAK2, TAP2, and PLCL1 Genes in a Consanguineous Arab Family With Multiple Autoimmune Diseases Including Celiac Disease

• Үндсэн зохиолчид: Arwa Mastoor Alharthi (Зохиогч), Babajan Banaganapalli (Зохиогч), Sabah M. Hassan (Зохиогч), Omran Rashidi (Зохиогч), Bandar Ali Al-Shehri (Зохиогч), Meshari A. Alaifan (Зохиогч), Bakr H. Alhussaini (Зохиогч), Hadeel A. Alsufyani (Зохиогч), Kawthar Saad Alghamdi (Зохиогч), Khalda Khalid Nasser (Зохиогч), Yagoub Bin-Taleb (Зохиогч), Ramu Elango (Зохиогч), Noor Ahmad Shaik (Зохиогч), Omar I. Saadah (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

BackgroundAutoimmune diseases (AIDs) share a common molecular etiology and often present overlapping clinical presentations. Thus, this study aims to explore the complex molecular basis of AID by whole exome sequencing and computational biology analysis.MethodsMolecular screening of the consanguineo...