Complex Inheritance of Rare Missense Variants in PAK2, TAP2, and PLCL1 Genes in a Consanguineous Arab Family With Multiple Autoimmune Diseases Including Celiac Disease

• Main Authors: Arwa Mastoor Alharthi (Author), Babajan Banaganapalli (Author), Sabah M. Hassan (Author), Omran Rashidi (Author), Bandar Ali Al-Shehri (Author), Meshari A. Alaifan (Author), Bakr H. Alhussaini (Author), Hadeel A. Alsufyani (Author), Kawthar Saad Alghamdi (Author), Khalda Khalid Nasser (Author), Yagoub Bin-Taleb (Author), Ramu Elango (Author), Noor Ahmad Shaik (Author), Omar I. Saadah (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundAutoimmune diseases (AIDs) share a common molecular etiology and often present overlapping clinical presentations. Thus, this study aims to explore the complex molecular basis of AID by whole exome sequencing and computational biology analysis.MethodsMolecular screening of the consanguineo...