Modulation of Butyrate Anticancer Activity by Solid Lipid Nanoparticle Delivery: An in Vitro Investigation on Human Breast Cancer and Leukemia Cell Lines

• Main Authors: Federica Foglietta (Author), Loredana Serpe (Author), Roberto Canaparo (Author), Nicoletta Vivenza (Author), Giovanna Riccio (Author), Erica Imbalzano (Author), Paolo Gasco (Author), Gian Paolo Zara (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Histone modification has emerged as a promising approach to cancer therapy. The short-chain fatty acid, butyric acid, a histone deacetylase (HD) inhibitor, has shown anticancer activity. Butyrate transcriptional activation is indeed able to withdraw cancer cells from the cell cycle, leading...