Role of Pharmacokinetic Effects in the Potentiation of Morphine Analgesia by L-Type Calcium Channel Blockers in Mice

• Autori principali: Norifumi Shimizu (Autore), Shiroh Kishioka (Autore), Takehiko Maeda (Autore), Yohji Fukazawa (Autore), Chizuko Yamamoto (Autore), Masanobu Ozaki (Autore), Hiroyuki Yamamoto (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2004-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The present study was designed to investigate the pharmacokinetic interaction of morphine with three classes of L-type calcium channel blockers (CCB) and its relationship to morphine-induced mechanical antinociception in mice. The CCB classes were benzothiazepine (diltiazem), dihydropyridine (nimodi...