Role of Pharmacokinetic Effects in the Potentiation of Morphine Analgesia by L-Type Calcium Channel Blockers in Mice

• Main Authors: Norifumi Shimizu (Author), Shiroh Kishioka (Author), Takehiko Maeda (Author), Yohji Fukazawa (Author), Chizuko Yamamoto (Author), Masanobu Ozaki (Author), Hiroyuki Yamamoto (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was designed to investigate the pharmacokinetic interaction of morphine with three classes of L-type calcium channel blockers (CCB) and its relationship to morphine-induced mechanical antinociception in mice. The CCB classes were benzothiazepine (diltiazem), dihydropyridine (nimodi...