Abrogation of Bronchial Eosinophilic Inflammation and Attenuated Eotaxin Content in Protease-Activated Receptor 2-Deficient Mice

• Main Authors: Toshiaki Takizawa (Author), Masaki Tamiya (Author), Takuya Hara (Author), Jiro Matsumoto (Author), Naohiro Saito (Author), Toru Kanke (Author), Junichi Kawagoe (Author), Yukio Hattori (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protease-activated receptor 2 (PAR2) belongs to the PAR family (PAR1 to PAR4), which is activated by serine proteases (trypsin, tryptase, etc.). In this study, we evaluated the role of PAR2 in allergic inflammation of airways using PAR2-deficient (PAR2−/−) mice. In wild-type mice, infiltration of eo...