Abrogation of Bronchial Eosinophilic Inflammation and Attenuated Eotaxin Content in Protease-Activated Receptor 2-Deficient Mice

• Автори: Toshiaki Takizawa (Автор), Masaki Tamiya (Автор), Takuya Hara (Автор), Jiro Matsumoto (Автор), Naohiro Saito (Автор), Toru Kanke (Автор), Junichi Kawagoe (Автор), Yukio Hattori (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2005-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Protease-activated receptor 2 (PAR2) belongs to the PAR family (PAR1 to PAR4), which is activated by serine proteases (trypsin, tryptase, etc.). In this study, we evaluated the role of PAR2 in allergic inflammation of airways using PAR2-deficient (PAR2−/−) mice. In wild-type mice, infiltration of eo...