Methylene Blue Inhibits the SARS-CoV-2 Spike-ACE2 Protein-Protein Interaction-a Mechanism that can Contribute to its Antiviral Activity Against COVID-19

• Main Authors: Damir Bojadzic (Author), Oscar Alcazar (Author), Peter Buchwald (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Due to our interest in the chemical space of organic dyes to identify potential small-molecule inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen of such compounds to assess their inhibitory activity against the interaction between SARS-CoV-2 spike protein and its cogna...