Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates

• Váldodahkkit: Severin Mairinger (Dahkki), Matthias Jackwerth (Dahkki), Ondřej Soukup (Dahkki), Matthias Blaickner (Dahkki), Clemens Decristoforo (Dahkki), Lukas Nics (Dahkki), Jens Pahnke (Dahkki), Marcus Hacker (Dahkki), Markus Zeitlinger (Dahkki), Oliver Langer (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: SpringerOpen, 2024-04-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Abstract Background 6-Bromo-7-[11C]methylpurine ([11C]BMP) is a radiotracer for positron emission tomography (PET) to measure multidrug resistance-associated protein 1 (MRP1) transport activity in different tissues. Previously reported radiosyntheses of [11C]BMP afforded a mixture of 7- and 9-[11C]m...