Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients

• Main Authors: Ane Bjerg Christensen (Author), Anders Dige (Author), Johan Vad-Nielsen (Author), Christel R. Brinkmann (Author), Mia Bendix (Author), Lars Østergaard (Author), Martin Tolstrup (Author), Ole S. Søgaard (Author), Thomas A. Rasmussen (Author), Jens Randel Nyengaard (Author), Jørgen Agnholt (Author), Paul W. Denton (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intestinal CD4+ T cell depletion is rapid and profound during early HIV-1 infection. This leads to a compromised mucosal barrier that prompts chronic systemic inflammation. The preferential loss of intestinal T helper 17 (Th17) cells in HIV-1 disease is a driver of the damage within the mucosal barr...