Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients

• Автори: Ane Bjerg Christensen (Автор), Anders Dige (Автор), Johan Vad-Nielsen (Автор), Christel R. Brinkmann (Автор), Mia Bendix (Автор), Lars Østergaard (Автор), Martin Tolstrup (Автор), Ole S. Søgaard (Автор), Thomas A. Rasmussen (Автор), Jens Randel Nyengaard (Автор), Jørgen Agnholt (Автор), Paul W. Denton (Автор)
• Формат: Книга
• Опубліковано: Hindawi Limited, 2015-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Intestinal CD4+ T cell depletion is rapid and profound during early HIV-1 infection. This leads to a compromised mucosal barrier that prompts chronic systemic inflammation. The preferential loss of intestinal T helper 17 (Th17) cells in HIV-1 disease is a driver of the damage within the mucosal barr...