Transdermal Delivery of Bioidentical Progesterone with a Steroid 5α-Reductase Inhibitor (Dutasteride): a Pilot Study

• Main Authors: sara Zargar-Shoshtari (Author), Hannaneh Wahhabaghei (Author), Abdolrasoul Mehrsai (Author), Jingyuan Wen (Author), Raid Alany (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Bioavailability of transdermal progesterone is low and variable. This may be attributed to transdermal metabolism by the 5α-reductase enzymes or the direct transport to the saliva. The objective of the current study was to evaluate the effect of enzyme inhibition on the bioavailability of t...