Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B-PKA-Caspase8/9 Pathway

• Main Authors: Jing-Li Tao (Author), Xuan Zhang (Author), Jia-Qi Zhou (Author), Cheng-Yu Li (Author), Ming-Hui Yang (Author), Zhao-Jun Liu (Author), Liang-Liang Zhang (Author), Shou-Long Deng (Author), Lu Zhang (Author), Ming Shen (Author), Guo-Shi Liu (Author), Hong-Lin Liu (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum an...