Advanced Glycated apoA-IV Loses Its Ability to Prevent the LPS-Induced Reduction in Cholesterol Efflux-Related Gene Expression in Macrophages

• Main Authors: Ligia Shimabukuro Okuda (Author), Rodrigo Tallada Iborra (Author), Paula Ramos Pinto (Author), Ubiratan Fabres Machado (Author), Maria Lucia Corrêa-Giannella (Author), Russell Pickford (Author), Tom Woods (Author), Margaret Anne Brimble (Author), Kerry-Anne Rye (Author), Marisa Passarelli (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We addressed how advanced glycation (AGE) affects the ability of apoA-IV to impair inflammation and restore the expression of genes involved in cholesterol efflux in lipopolysaccharide- (LPS-) treated macrophages. Recombinant human apoA-IV was nonenzymatically glycated by incubation with glycolaldeh...