Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

• Main Authors: Matteo Stravalaci (Author), Francesca Davi (Author), Raffaella Parente (Author), Marco Gobbi (Author), Barbara Bottazzi (Author), Alberto Mantovani (Author), Anthony J. Day (Author), Simon J. Clark (Author), Mario R. Romano (Author), Antonio Inforzato (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement fa...