Carboxymethyl chitosan prolongs adenovirus‐mediated expression of IL‐10 and ameliorates hepatic fibrosis in a mouse model

• Main Authors: Yannian Gou (Author), Yaguang Weng (Author), Qian Chen (Author), Jinghong Wu (Author), Hao Wang (Author), Jiamin Zhong (Author), Yang Bi (Author), Daigui Cao (Author), Piao Zhao (Author), Xiangyu Dong (Author), Meichun Guo (Author), William Wagstaff (Author), Bryce Hendren‐Santiago (Author), Connie Chen (Author), Andrew Youssef (Author), Rex C. Haydon (Author), Hue H. Luu (Author), Russell R. Reid (Author), Le Shen (Author), Tong‐Chuan He (Author), Jiaming Fan (Author)
• Format: Book
• Published: Wiley, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Effective and safe liver‐directed gene therapy has great promise in treating a broad range of liver diseases. While adenoviral (Ad) vectors have been widely used for efficacious in vivo gene delivery, their translational utilities are severely limited due to the short duration of transgene...