Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation

• Main Authors: Jing Lu (Author), Jingyan Li (Author), Yuehuai Hu (Author), Zhen Guo (Author), Duanping Sun (Author), Panxia Wang (Author), Kaiteng Guo (Author), Dayue Darrel Duan (Author), Si Gao (Author), Jianmin Jiang (Author), Junjian Wang (Author), Peiqing Liu (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes. However,...