xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers

• Main Authors: Namgyu Lee (Author), Anne E. Carlisle (Author), Austin Peppers (Author), Sung Jin Park (Author), Mihir B. Doshi (Author), Meghan E. Spears (Author), Dohoon Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inducers of ferroptosis such as the glutathione depleting agent Erastin and the GPX4 inhibitor Rsl-3 are being actively explored as potential therapeutics in various cancers, but the factors that determine their sensitivity are poorly understood. Here, we show that expression levels of both subunits...