Polymorphisms and haplotypes in the promoter of the TNF-α gene are associated with disease severity of severe fever with thrombocytopenia syndrome in Chinese Han population.

• Main Authors: Bo Xing (Author), Xiao-Kun Li (Author), Shao-Fei Zhang (Author), Qing-Bin Lu (Author), Juan Du (Author), Pan-He Zhang (Author), Zhen-Dong Yang (Author), Ning Cui (Author), Chen-Tao Guo (Author), Wu-Chun Cao (Author), Xiao-Ai Zhang (Author), Wei Liu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that is caused by a novel bunyavirus, SFTSV. We assessed whether the single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-α) were associated with risk to severity of SFTS. Five TNF-α SNPs (...