Effect of NAT2, GSTM1 and CYP2E1 genetic polymorphisms on plasma concentration of isoniazid and its metabolites in patients with tuberculosis, and the assessment of exposure-response relationships

• Main Authors: Viktorija Ulanova (Author), Agnija Kivrane (Author), Anda Viksna (Author), Leonora Pahirko (Author), Lauma Freimane (Author), Darja Sadovska (Author), Iveta Ozere (Author), Andra Cirule (Author), Eduards Sevostjanovs (Author), Solveiga Grinberga (Author), Dace Bandere (Author), Renate Ranka (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Isoniazid is a key drug in the chemotherapy of tuberculosis (TB), however, interindividual variability in pharmacokinetic parameters and drug plasma levels may affect drug responses including drug induced hepatotoxicity. The current study investigated the relationships between isoniazid...