Complex dispersions of poloxamers and mesoporous carriers with ibrutinib

• Main Authors: Igor A. Dain (Author), Sergey A. Zolotov (Author), Natalia B. Demina (Author), Anna S. Zolotova (Author), Grigorii A. Buzanov (Author), Vasilii M. Retivov (Author), Yevgenii S. Ponomaryov (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ibrutinib is an anticancer drug, a Bruton's tyrosine kinase inhibitor with poor solubility in aqueous media. This study reports on the study of the effectiveness of mesoporous carriers based on magnesium aluminometasilicate and poloxamers to improve the solubility and bioavailability of ibrutin...