Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer

• Main Authors: Morgan W. B. Kirzinger (Author), Frederick S. Vizeacoumar (Author), Bjorn Haave (Author), Cristina Gonzalez-Lopez (Author), Keith Bonham (Author), Anthony Kusalik (Author), Franco J. Vizeacoumar (Author)
• Format: Book
• Published: BMC, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Synthetic lethal interactions (SLIs) that occur between gene pairs are exploited for cancer therapeutics. Studies in the model eukaryote yeast have identified ~ 550,000 negative genetic interactions that have been extensively studied, leading to characterization of novel pathways...