Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates

• Main Authors: Simone Giovannuzzi (Author), Anil Kumar Marapaka (Author), Nader S. Abutaleb (Author), Fabrizio Carta (Author), Hsin-Wen Liang (Author), Alessio Nocentini (Author), Luigi Pisano (Author), Mohamed N. Seleem (Author), Daniel P. Flaherty (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug targets. Here we explored the inhibition of the α-CA from N. gonorrhoeae (α-NgCA), of α- and γ-class enzymes from Enterococcus fae...