Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model

• Main Authors: Joske Millecam (Author), Thomas van Bergen (Author), Stijn Schauvliege (Author), Gunther Antonissen (Author), Ann Martens (Author), Koen Chiers (Author), Ronette Gehring (Author), Elke Gasthuys (Author), Johan Vande Walle (Author), Siska Croubels (Author), Mathias Devreese (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studies, but also to gain knowledge on the pharmacokinetic and pharmacodynamic properties of the drug. Recently, the conventional growing p...