Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

Bile acids have been shown to inhibit human (h) carbonic anhydrases (CA, EC 4.2.1.1) along the gastrointestinal tract, including hCA II. The elucidation of the hormonal inhibition mechanism of the bile acid cholate to hCA II was provided in 2014 by X-ray crystallography. Herein, we extend the inhibi...

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Main Authors: Alessio Nocentini (Author), Alessandro Bonardi (Author), Paola Gratteri (Author), Bruno Cerra (Author), Antimo Gioiello (Author), Claudiu T. Supuran (Author)
Format: Book
Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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